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Effective Solutions for Membrane Protein Expression

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Because GPCR (G Protein Coupled Receptors) form the biggest family of receptors located on the surface of human cells, they represent 50% of medicines and therapies currently available on the market (in financial terms this represents more than 30 Billion USD in annual drug sales). Current trends dictate that Cancer has now overtaken cardiovascular illnesses as a key priority in healthcare - consequently all research relating to GPCR has the potential to lead to promising new therapies or medications.

Synthelis: a major step forward in the production of membrane proteins

Synthelis is a business unit which provides a solution to a well known challenge in terms of biotechnological production - namely the synthesized production of membrane proteins.

Synthelis is the only organization in Europe that specializes solely in the production of membrane proteins.

Around 30% of the human genome is coded for protein membranes. This family of proteins is involved in key biological processes such as cellular signaling, energy transduction or metabolic transportation. Anomalies affecting their structure or function can be directly or indirectly linked to a large number of pathologies. Consequently these molecules are the target for a large number of medicines currently planned for development. The significant difficulties associated with their production, purification and crystallization in comparison with soluble proteins demonstrates the necessity for developing new manufacturing processes.

Using a cutting-edge process, Synthelis produces functional membrane proteins in soluble or proteoliposome form. These membrane proteins can be used in structural studies or functional/electrophysiological studies, the development of vaccines or even high throughput molecule/ligand screening.

membrane protein.jpgThe Synthelis offering

  • Active proteoliposomes containing one or more different membrane proteins and preserved protein functionality
  • Customised soluble membrane proteins

 

A Flexible approach to membrane expression

Membrane proteins in all of the following areas can be supplied:

  • Membrane proteins originating from different sources (plant, bacteria, mammals)
  • Membrane proteins of different types (ion channels, porins, GPCRs, virus etc)
  • 40 membrane proteins already successfully expressed in native and active forms

Key benefits

  • The entire protein is produced using Synthelis's patented process
  • Proteins are active (fully functional)
  • Large quantities can be produced (in Mgs) quickly (between 2-3 months)
  • Proteins produced demonstrate very high levels of purity

Production Process

The following schematic outlines the production process leading to the production of active membrane proteins

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R&D Areas Addressed

We can support you in all of the following areas:

  • Structural studies (crystallogenesis / NMR)
  • Functional studies (Enzymatic assays)
  • Target proteins for rational drug design
  • Membrane proteins for microarrays
  • Anti-MP antibodies production
  • Protein-Protein/ Ligand interaction studies
  • Therapeutic protein development
  • Vaccine Development
Contacts
Rémy Beroud
Product Manager
+33 (0)4 76 00 78 46
This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 
 

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TESTIMONIALS

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