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Synthesis of peptidic toxins : access to an immense library of active peptides  (suitable for use in the development of new drugs and therapies)

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Toxins extracted from spiders, molluscs and snakes have enabled the pharmacological characterization of a large number of ionic channels. Although pharmacological understanding of ionic channels is still limited, the discovery of active agents could play a significant role in the understanding of the physiological function of potential new targets.

Within this context, Smartox is a business unit that specialises in the synthesis of bespoke peptidic toxins. These toxins demonstrate significant potential as a result of their action on Ionic channels and G-protein coupled receptors. Smartox works alongside research teams with a view to identifying and characterizing the interactions between ionic channels and toxins. Many of the resulting molecules can then form the basis of medications or therapies planned for future development. Visit http://www.smartox-biotech.com for more information

Range of services

  • Bespoke synthesis of peptidic toxins
  • R&D consulting services available
  • Significant library of toxins available (20 toxins catalogued per month)
  • Customisable: toxins can be modified according to clients' specific needsimage2.jpg

Key benefits

  • Synthesis carried out by microwave ensuring high levels of quality and speed of production
  • Expertise of Director of Science: Michel De Waard recognized as a leading expert in the study of ionic channels
  • Able to provide highly innovative toxins (previously uncommercialised)
  • Capable of producing large quantities of toxins within a short time frame (under 20 days)

Potential Applications

  • Drug discovery
  • Drug Development
  • Vaccine development

Technical Data

  • < 70 amino acids
  • Toxins originate from animals, plants, bacteria, fungi etc
  • Mass spectrometry (MALDI-TOF) and HPLC analysis
  • HPLC purification and profile
  • Peptide sequence and folding guaranteed

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ω CONOTOXIN MVIIC HPLC profile

 

Modification capabilities

  • Click chemistry
  • N-terminal acylation
  • C-terminal amidation
  • Biotinylation
  • Fluorescent tag
  • Incorporation of non natural amino acids
  • Cyclic and phosphorylated peptides
  • C13 and N15 isotope labelled
  • Other modifications upon request

Contacts
Rémy Beroud
+33 (0)4 76 00 78 46
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http://www.smartox-biotech.com
 

TECHNOLOGY FOCUS

TESTIMONIALS

« When we identified Professor Drouet's technology at the UJF it was immediately apparent that this invention met all our needs." T Paper - Biosynex
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